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🧪 Chemical Method Validation
ICH Q2 / GB 27404: LOD/LOQ · spike recovery · precision RSD% · linearity r²
① LOD/LOQ (detection / quantitation limit)
Replicate blank readings (space/newline separated) + sensitivity S (calibration slope)
② Spike recovery
Each line "added amount measured increment" (multiple lines allowed)
③ Precision RSD%
Replicate readings of the same sample (space/newline separated)
④ Linearity r²
≥3 points, each line "concentration response"
Notes
· LOD=3.3·s/S, LOQ=10·s/S (k adjustable); recovery recommended 90%~110% (80%~120% for complex matrices); RSD% per method requirements; linearity r²≥0.995 is generally good.
· The four sections are independent; compute whichever you fill in.
About Chemical Method Validation
Chemical method validation calculator per ICH Q2 and ISO/IEC 17025: accuracy, precision, linearity, LOD and LOQ with acceptance judgments.
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